Andras Nagy MD, PhD
Professor
Research
Andras Nagy
Location
Lunenfeld-Tannenbaum Research Institute
Research Interests
Stem cells, cancer, cell reprogramming

Dr. Nagy is currently a Senior Scientist at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Professor in the Department of Obstetrics & Gynaecology and Institute of Medical Science at the University of Toronto, and Investigator at the McEwen Centre for Regenerative Medicine. He also holds a Tier I Canada Research Chair in Stem Cells and Regeneration. 

His research focuses on several areas of interest, which include

  1. Functional studies of genes belonging to families with known roles in blood vessel formation;
  2. Development of sophisticated genetic manipulation tools in the mouse model;
  3. Applying genetics to cancer research;
  4. Stem cell therapeutics;
  5. Exploring the molecular mechanisms underlying the reprogramming of somatic cells to pluripotent stem and lineage committed progenitor cells.

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A. (2014) Genome-wide characterization of the routes to pluripotency. Nature. 2014 Dec 11;516(7530):198-206.

Tonge PD, Corso AJ, Monetti C, Hussein SM, Puri MC, Michael IP, Li M, Lee DS, Mar JC, Cloonan N, Wood DL, Gauthier ME, Korn O, Clancy JL, Preiss T, Grimmond SM, Shin JY, Seo JS, Wells CA, Rogers IM, Nagy A. (2014) Divergent reprogramming routes lead to alternative stem-cell states. Nature. 2014 Dec 11;516(7530):192-7.

Benevento M, Tonge PD, Puri MC, Hussein SM, Cloonan N, Wood DL, Grimmond SM, Nagy A, Munoz J, Heck AJ. (2014) Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks. Nat Commun. 2014 Dec 10;5:5613.

Clancy JL, Patel HR, Hussein SM, Tonge PD, Cloonan N, Corso AJ, Li M, Lee DS, Shin JY, Wong JJ, Bailey CG, Benevento M, Munoz J, Chuah A, Wood D, Rasko JE, Heck AJ, Grimmond SM, Rogers IM, Seo JS, Wells CA, Puri MC, Nagy A, Preiss T. (2014) Small RNA changes en route to distinct cellular states of induced pluripotency. Nat Commun. 2014 Dec 10;5:5522. 

Lee DS, Shin JY, Tonge PD, Puri MC, Lee S, Park H, Lee WC, Hussein SM, Bleazard T, Yun JY, Kim J, Li M, Cloonan N, Wood D, Clancy JL, Mosbergen R, Yi JH, Yang KS, Kim H, Rhee H, Wells CA, Preiss T, Grimmond SM, Rogers IM, Nagy A, Seo JS. (2014) An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator. Nat Commun. 2014 Dec 10;5:5619. 

Li H, Qu D, McDonald A, Isaac SM, Whiteley KJ, Sung HK, Nagy A and Adamson SL. (2014). Trophoblast-Specific Reduction of VEGFA Alters Placental Gene Expression and Maternal Cardiovascular Function in Mice. Biol Reprod. 2014 Oct;91(4):87.

Onishi K, Tonge PD, Nagy A, Zandstra P. (2014) Local BMP-SMAD1 Signaling Increases LIF Receptor-Dependent STAT3 Responsiveness and Primed-to-Naive Mouse Pluripotent Stem Cell Conversion Frequency. Stem Cell Reports. 2014 Jun 6;3(1):156-68.

Michael IP, Westenskow PD, Hacibekiroglu S, Cohen Greenwald A, Ballios BG, Kurihara T, Li Z, Warren CM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-Arispe ML, Rini JM, van der Kooy D, Friedlander M, Nagy A. (2014) Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med. 2014 May 1;6(5):604-23.

Behringer R., Gertsensten M., Vintersten K. and Nagy A.(2013) Manipulating the Mouse Embryo; A Laboratory manual. 4rd edition, Cold Spring Harbor Press, Cold Spring Harbor, New York

Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SML, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson A, Nagy A. (2013) Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis. Cell Metabolism. Volume 17, Issue 1, 61-72, 8 January 2013