Christine Derzko MD, FRCS(C)
Associate Professor
Reproductive Endocrinology & Infertility


St. Michael's Hospital

Clinical Interests

osteoporosis, menopause, POI, gynecological consequences of cancer therapies, gynecological consequences of breast cancer, endocrine complications of pregnancy, phytoestrogens, SPRMs, fibroids, hormones and cognition, hormones and traumatic brain injury

Dr Christine Derzko is an Associate Professor in Obstetrics & Gynecology, is member of the Division of Reproductive Endocrinology and Infertility and holds a cross appointment to the Department of Medicine Division of Endocrinology at UofT and at St, Michael’s Hospital.  Following undergraduate studies and residency training in Obstetrics & Gynecology at UofT she did a combined fellowship in Toronto and at UCLA in reproductive endocrinology, pediatric gynecology and pediatric endocrinology and in 2006 achieved a Certificate in Education from the Faculty of Medicine at the UofT.

Dr. Derzko’s clinical duties, in addition to General Obstetrics & Gynaecology, are focused in the areas of Reproductive Endocrinology, Menopause and Osteoporosis/Metabolic Bone Diseases.  Her academic activities include teaching undergraduates as well as residents/fellows and many elective students.  She is deeply involved in developing continuing medical education programs including seminars, lectures, webinars and on-line programs and conferences for physicians and pharmacists and is herself a frequently invited speaker.    


Research Synopsis

Dr. Derzko's current research involves clinical trials of new osteoporosis drugs, hormonal and non-hormonal menopause therapies as well as non-invasive breast evaluation and breast cancer reduction strategies.  


Princess Margaret Hospital Foundation Weekend Walkers Breast Cancer Innovation Fund. Use of Optical Breast Spectroscopy to evaluate early  breast tissue changes in post-menopausal women after initiation of menopausal hormone therapy Co-PIs: Lothar Lilge and Christine Derzko

Canada Research Chair discretionary funds. A Retrospective chart review to assess the effects of a high soy protein diet on endometrial thickness and vaginal maturation index. PIs: Dr. D. Jenkins and  C. Derzko

Publications and Awards

Recent Publications

Khan A, Dubois S, Khan AA, Rahman MZ, Khan OA, Syed HT, Derzko C. A randomized, double-blind, placebo-controlled study to evaluate the effects of alendronate on bone mineral density and bone remodelling in perimenopausal women with low bone mineral density.  J Obstet Gynaecol Can. 2014 Nov;36(11):976-82.

Archer DF, Pinkerton JV, Guico-Pabia CJ, Hwang E, Cheng RF; Study 3353 Investigators. Cardiovascular, cerebrovascular, and hepatic safety of desvenlafaxine for 1 year in women with vasomotor symptoms associated with menopause.  Menopause. 2013 Jan;20(1):47-56. doi: 10.1097/gme.0b013e3182775fe9.

Pinkerton JV, Constantine G, Hwang E, Cheng RF; Study 3353 Investigators. Desvenlafaxine compared with placebo for treatment of menopausal vasomotor symptoms: a 12-week, multicenter, parallel-group, randomized, double-blind, placebo-controlled efficacy trial. Menopause. 2013 Jan;20(1):28-37. doi: 10.1097/gme.0b013e31826421a8.

Ghosh N, Luk A, Derzko C, Dorian P, Chow C-M   The Acute Treatment of Maternal Supraventricular Tachycaridas During Pregnancy : A Review of the Literature J Obstet Gynaecol Can 2011, 33(1):17-23                                                                                 

Response Letter to the Editor: Adenosine for Maternal Tachycardia and Preterm Delivery.Nina Ghosh MD, Adriana Luk MD, Christine Derzko MD, Paul Dorian MD, and Chi-Ming Chow MD. J Obstet Gynaecol Can 2011; 33(8):794-795. 

Derzko CM. Bioidentical Hormone Therapy. Endocrinology Rounds 2009;9(5):1-6. 

Derzko CM.  DEPO-PROVERA and Bone Loss: Position Statement for Osteoporosis Canada  Osteoporosis Update (2008)

Derzko C, Elliott S, Lam W.  Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol. 2007 Dec;14 Suppl 1:S20-40. 

Derzko CM. Menopause, Hormones and the “Critical Therapeutic Window”.  Endocrinology Rounds 2007;7(1):1-6.

Shifren JL, Davis SR, Moreau M, Waldbaum A, Bouchard C, DeRogatis L, Derzko C, Bearnson P, Kakos N, O'Neill S, Levine S, Wekselman K, Buch A, Rodenberg C, Kroll R. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study.Menopause. 2006 Sep-Oct;13(5):770-9. Erratum in: Menopause. 2007 Jan-Feb;14(1):157.

Demers C, Derzko C, David M, Douglas J;. Gynaecological and obstetric management of women with inherited bleeding disorders.(SOGC) Int J Gynaecol Obstet. 2006 Oct;95(1):75-87.                                                                                         


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