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Robert Casper
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Faculty Profile

Robert F. Casper

Contact Information:
Mailing Address: 150 Bloor Street West, Suite 210
Toronto, Ontario, M5S 2X9
Telephone: 416-972-0777
Fax: 416-972-0036
E-mail address: rfcasper@aol.com

Degrees & Professional Designations:
  • M.D. University of Western Ontario, 1973
  • F.R.C.S.C Royal College of Surgeons (Canada), 1977
  • FLEX Federation Licensing Examination, 1978
  • DIPLOMATE American Board of Obstetrics and Gynecology, 1981
  • DIPLOMATE American
  • Board of Obstetrics and Gynecology, Division of Reproductive Endocrinology, 1982

Academic Position: Professor

Primary Appointment: Department of Obstetrics and Gynecology

Cross Appointments:
Professor, Department of Medicine, Division of Endocrinology, University of Toronto
Professor, Faculty of Dentistry, Graduate Department of Dentistry, University of Toronto
Professor, Department of Physiology, University of Toronto

Hospital Affiliation/Practice Location: Mount Sinai Hospital

Key Interests: Research

Current Research Grants and Projects:
2002-2006 CIHR – Operating Grant – MOP -57885
“Novel strategies to control cytokine networks for the modulation of hematopoietic stem cell self-renewal and differentiation.
Principal Applicant: Dr. Peter Zandstra
Co-Investigator: Dr. Robert F. Casper
Amount: $124,000 per/year

2003-2007 CIHR–Operating/Strategic Initiative: Healthy Gametes and Great Embryos # HGG-62292
“Aromatase inhibitors to increase implantation rates in human IVF.”
Project Leader: Dr. T. Kennedy:
Main Project Title: “Towards Single Embryo Transfer in the Human”
Principal Applicant: Dr. Robert F. Casper
Amount: $91,440 per/year

2003–2006 CIHR-Operating Grant – MOP-64234
“Identification of early pathogenetic events leading to endometriosis and discovery of novel therapeutic strategies.”
Principal Applicant: Dr. Robert F. Casper
Amount: $138,598/year

2005-2010 CIHR-Operating Grant – MOP 14058
“Enhancing early embryo development in assisted reproduction”
Principal Applicants: Dr. Robert F. Casper and Dr. Andrea Jurisicova
Co-Applicant: Dr. Gloria I. Perez
Amount: $121,240/year

2005-2010 CIHR-Group Program
“Development and Fetal Health”
Principal Applicant: Dr. S.Lee Adamson
Co-Applicant: Drs. R.F. Casper, A. Jurisicova
Amount: $375,250/year

2003-2008 Insception Biosciences Inc
“Hematopoietic stem cell expansion and differentiation for tissue therapeutics”
Co-principal applicants: Dr Robert Casper and Dr Ian Rogers
Amount: $315,000/yr

Description:
Dr Casper’s research is in the area of Reproductive Science with the predominant aim of translating basic physiologic and molecular discoveries into clinical applications. Major areas of interest include assisted reproductive technology including ovulation induction, endometriosis, hematopoietic stems cells and the adverse effects of environmental lighting and cigarette smoke toxicants on human health.

Recent/Key Publications:
1. Bedaiwy MA, Falcone T, Mascha EJ, Casper RF. Genetic polymorphism in the fibrinolytic system is associated with endometriosis: a potential etiologic mechanism. Obstet Gynecol in press, June, 2006

2. Mitwally MF, Biljan MM, Casper RF. (2005) Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. American Journal of Obstetrics and Gynecology. 192:381-386.

3. Esfandiari N, Gotlieb L, Casper RF (2005). Live birth of healthy triplets after in vitro fertilization and embryo transfer in an acromegalic woman with elevated growth hormone. Fert Ster 83(4):1041.

4. Kayumov L, Casper RF, Hawa RJ, Perelman B, Chung SA, Sokalsky S, Shapiro CM. (2005) Blocking low-wavelength light prevents nocturnal melatonin suppression with no adverse effect on performance during simulated shift work. J Clin Endocrinol Metab. 90(5):2755-2761.

5. Casper RF. (2005) Are recombinant gonadotrophins safer, purer and more effective than urinary gonadotrophins? Reprod Biomed Online 11(5):539-540.

6. Esfandiari N, Ryan EAJ, Gotlieb L, Casper RF. (2005) Successful pregnancy following transfer of embryos from oocytes with abnormal zona pellucida and cytoplasm morphology. Case Report. Reproductive Biomedicine Online Journal. 11(5):620-623

7. Madlambayan GJ, Rogers I, Kirouac DC, Yamanaka N, Mazurier F, Doedens M, Casper RF, Dick JE, Zandstra PW. (2005) Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Experimental Hematology. 33(10):1229-1239.

8. Casper RF. (2006) Is paroxetine an effective treatment for hot flashes? Nature Clinical Practice Endocrinology & Metabolism (In press).