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John Kingdom
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Faculty Profile



 

John Kingdom


Contact Information:

Mailing Address:

Department of Obstetrics & Gynaecology
Mount Sinai Hospital
600 University Avenue, OPG 3-904
Toronto, Ontario M5G 1X5 Canada

Phone Number:

416-586-8764 (assistant:  Ms. Nancy Moniz)

Fax Number:

416-586-8565

Email Address:

jkingdom@mtsinai.on.ca

Degrees & Professional Designations:

  • Bachelor of Medicine and Surgery, Trinity College Dublin, Ireland 1984
  • Doctorate of Medicine, University of Glasgow, UK 1992
  • MRCP (Paediatrics) 1987
  • MRCOG 1990
  • FRCSC Obstetrics & Gynaecology 1998
  • FRCOG 2002
  • FRCSC Maternal-Fetal Medicine 2008
  • Rose Torno Chair in Obstetrics & Gynaecology at Mount Sinai Hospital 2005

Academic Position: Professor since 2004

Primary Appointment: Department of Obstetrics and Gynaecology

Cross Appointments:

  • Department of Laboratory Medicine and Pathobiology, 2005
  • Department of Medical Imaging, 2008
  • Department of Physiology, 2012

Hospital Affiliation/Practice Location: Mount Sinai Hospital

Key Interests:

  • Placental development
  • Molecular pathology of placental dysfunction syndromes
  • Screening, diagnosis and management of placental disorders

Current Research Grants and Projects:

  • Villous trophoblast Turnover
  • CIHR 2010-2014 (2nd renewal)
  • Non-anticoagulant actions of Heparin: Implications for the Prevention of Severe Pre-eclampsia
  • CIHR 2012-2016 (new grant)
  • Interaction between Heparin and Placental Villi
  • Physician’s Services Inc. 2011-2013 (new grant)
  • Screening for Placental Dysfunction in Healthy Nulliparous Women
  • AFP Innovation Fund, MSH-UHN, 2011-2013

Description:

The research interests of the “Kingdom Group” synergize between a small group of CIHR-funded scientists based in the Lye Laboratory of the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, the Department of Cardiology research group at Mount Sinai Hospital and the Placenta Clinic at the Special Pregnancy Program in the Ontario Power Generation Building, part of the Frances Bloomberg Centre for Women's and Infants' Health.  Our overall goal is to understand the molecular basis of placental dysfunction that mediates combinations of intrauterine growth restriction (IUGR), severe pre-eclampsia, stillbirth and abruption.  Our ability to study these conditions effectively in the laboratory is made possible by our BioBank Team at Mount Sinai Hospital. Our links between the Placenta Clinic and Cardiology allow us to study the maternal response to normal and abnormal placentation, assessed non-invasively in high-risk pregnancies. We are refining the choice of screening tools to effectively identify truly high-risk, from relatively-normal pregnancies, through our prospective “Placental Health Study in Nulliparous Women”.  This study began recruitment in February 2012.  We envision the study will continue for 5 years, include capture of the majority of placentas at delivery to thereby create a powerful research resource for future trainees.  Our group includes trainees across the full spectrum including pre-clinical and medical students, and clinical trainees.  New collaborative projects for 2013 include; in-vivo cardiovascular response of women at high risk of severe pre-eclampsia to Heparin (PI = Dr. John Kingdom) and the relationship between fetal cardiac function and brain perfusion in IUGR pregnancies (PI = Dr. Mike Seed, Hospital for Sick Children).

Recent/Key Publications:  PubMed publications for Kingdom, John  (Search on Kingdom J, OR Kingdom JC, OR Kingdom JCP)