Research News

Our faculty have a distinguished publication record. 

Below is a list of recently published articles by our faculty members.

For a complete list of scientific publications by our Department's faculty members, please visit PubMed. 

Genome-wide characterization of the routes to pluripotency.
Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A.
Nature. 2014 Dec 11;516(7530):198-206. doi: 10.1038/nature14046. PMID: 25503233 

Divergent reprogramming routes lead to alternative stem-cell states.
Tonge PD, Corso AJ, Monetti C, Hussein SM, Puri MC, Michael IP, Li M, Lee DS, Mar JC, Cloonan N, Wood DL, Gauthier ME, Korn O, Clancy JL, Preiss T, Grimmond SM, Shin JY, Seo JS, Wells CA, Rogers IM, Nagy A.
Nature. 2014 Dec 11;516(7530):192-7. doi: 10.1038/nature14047. PMID: 25503232 

Small RNA changes en route to distinct cellular states of induced pluripotency.
Clancy JL, Patel HR, Hussein SM, Tonge PD, Cloonan N, Corso AJ, Li M, Lee DS, Shin JY, Wong JJ, Bailey CG, Benevento M, Munoz J, Chuah A, Wood D, Rasko JE, Heck AJ, Grimmond SM, Rogers IM, Seo JS, Wells CA, Puri MC, Nagy A, Preiss T.
Nat Commun. 2014 Dec 10;5:5522. doi: 10.1038/ncomms6522. PMID: 25494340 

An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator.
Lee DS, Shin JY, Tonge PD, Puri MC, Lee S, Park H, Lee WC, Hussein SM, Bleazard T, Yun JY, Kim J, Li M, Cloonan N, Wood D, Clancy JL, Mosbergen R, Yi JH, Yang KS, Kim H, Rhee H, Wells CA, Preiss T, Grimmond SM, Rogers IM, Nagy A, Seo JS.
Nat Commun. 2014 Dec 10;5:5619. doi: 10.1038/ncomms6619. PMID: 25493341 

Less-tight versus tight control of hypertension in pregnancy.
Magee LA, von Dadelszen P, Rey E, Ross S, Asztalos E, Murphy KE, Menzies J, Sanchez J, Singer J, Gafni A, Gruslin A, Helewa M, Hutton E, Lee SK, Lee T, Logan AG, Ganzevoort W, Welch R, Thornton JG, Moutquin JM.
N Engl J Med. 2015 Jan 29;372(5):407-17. doi: 10.1056/NEJMoa1404595. PMID: 25629739

Insulin detemir does not cross the human placenta.
Suffecool K, Rosenn B, Niederkofler EE, Kiernan UA, Foroutan J, Antwi K, Ribar A, Bapat P, Koren G.
Diabetes Care. 2015 Feb;38(2):e20-1. doi: 10.2337/dc14-2090. PMID: 25614695 

Preeclampsia: An Old Disease with New Tools for Better Diagnosis and Risk Management.
Abou El Hassan M, Diamandis EP, Karumanchi SA, Shennan AH, Taylor RN.
Clin Chem. 2015 Jan 22. pii: clinchem.2014.230565. [Epub ahead of print]. PMID: 25614469 

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER negative breast cancer.
Kabisch M, Bermejo JL, Dünnebier T, Ying S, Michailidou K, et al.
Carcinogenesis. 2015 Jan 13. pii: bgu326. [Epub ahead of print]. PMID: 25586992

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Kuchenbaecker KB, Ramus SJ, Tyrer J, Lee A, Shen HC, et al. 
Nat Genet. 2015 Feb;47(2):164-71. doi: 10.1038/ng.3185. Epub 2015 Jan 12. PMID: 25581431 

Assessment tool for total laparoscopic hysterectomy: a delphi consensus survey among international experts.
Tremblay C, Grantcharov T, Urquia ML, Satkunaratnam A.
J Obstet Gynaecol Can. 2014 Nov;36(11):1014-23. PMID: 25574680

The effect of age, ethnicity, and level of education on fertility awareness and duration of infertility.
Swift BE, Liu KE.
J Obstet Gynaecol Can. 2014 Nov;36(11):990-6. PMID: 25574676

A randomized, double-blind, placebo-controlled study to evaluate the effects of alendronate on bone mineral density and bone remodelling in perimenopausal women with low bone mineral density.
Khan A, Dubois S, Khan AA, Rahman MZ, Khan OA, Syed HT, Derzko C.
J Obstet Gynaecol Can. 2014 Nov;36(11):976-82. PMID: 25574674

Abdominal adiposity and insulin resistance in early pregnancy.
De Souza LR, Kogan E, Berger H, Alves JG, Lebovic G, Retnakaran R, Maguire JL, Ray JG.
J Obstet Gynaecol Can. 2014 Nov;36(11):969-75. PMID: 25574673 

Perceptions of a night float system of resident call within an obstetrics and gynaecology residency training program.
Shirreff L, Shapiro JL, Yudin MH.
J Obstet Gynaecol Can. 2014 Nov;36(11):957-61. PMID: 25574671

Pregnancy risks in women with pre-existing coronary artery disease, or following acute coronary syndrome.
Burchill LJ, Lameijer H, Roos-Hesselink JW, Grewal J, Ruys TP, Kulikowski JD, Burchill LA, Oudijk MA, Wald RM, Colman JM, Siu SC, Pieper PG, Silversides CK.
Heart. 2015 Jan 6. pii: heartjnl-2014-306676. doi: 10.1136/heartjnl-2014-306676. [Epub ahead of print] PMID: 25564557

Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia.
Pereira-Terra P, Deprest JA, Kholdebarin R, Khoshgoo N, DeKoninck P, Boerema-De Munck AA, Wang J, Zhu F, Rottier RJ, Iwasiow BM, Correia-Pinto J, Tibboel D, Post M, Keijzer R.
Ann Surg. 2015 Jan 5. [Epub ahead of print] PMID: 25563880

The Distribution of Clinical Phenotypes of Preterm Birth Syndrome: Implications for Prevention.
Barros FC, Papageorghiou AT, Victora CG, Noble JA, Pang R, et al. 
JAMA Pediatr. 2015 Jan 5. doi: 10.1001/jamapediatrics.2014.3040. [Epub ahead of print] PMID: 25561016 

Current practices in the prediction and prevention of preterm birth in patients with higher-order multiple gestations.
Baker E, Hunter T, Okun N, Farine D.
Am J Obstet Gynecol. 2014 Dec 30. pii: S0002-9378(14)02490-9. doi: 10.1016/j.ajog.2014.12.031. [Epub ahead of print] PMID: 25555660

Medical treatment of ureteral obstruction associated with ovarian remnants and/or endometriosis: report of 3 cases and review of the literature.
Vilos GA, Marks-Adams JL, Vilos AG, Oraif A, Abu-Rafea B, Casper RF.
J Minim Invasive Gynecol. 2014 Dec 19. pii: S1553-4650(14)01746-4. doi: 10.1016/j.jmig.2014.12.153. [Epub ahead of print] PMID: 25533869 

Performance characteristics of a brief Family History Questionnaire to screen for Lynch syndrome in women with newly diagnosed endometrial cancer.
Eiriksson L, Aronson M, Clarke B, Mojtahedi G, Massey C, Oza AM, Gallinger S, Pollett A, Mackay H, Bernardini MQ, Ferguson SE.
Gynecol Oncol. 2014 Dec 19. pii: S0090-8258(14)01612-6. doi: 10.1016/j.ygyno.2014.12.023. [Epub ahead of print] PMID: 25529831

Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1.
Glubb DM, Maranian MJ, Michailidou K, Pooley KA, Meyer KB, et al.
Am J Hum Genet. 2015 Jan 8;96(1):5-20. doi: 10.1016/j.ajhg.2014.11.009. Epub 2014 Dec 18. PMID: 25529635 

Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study.
Lee AW, Tyrer JP, Doherty JA, Stram DA, Kupryjanczyk J, et al.
Gynecol Oncol. 2014 Dec 17. pii: S0090-8258(14)01572-8. doi: 10.1016/j.ygyno.2014.12.017. [Epub ahead of print] PMID: 25528498

Assisted reproduction involving gestational surrogacy: an analysis of the medical, psychosocial and legal issues: experience from a large surrogacy program.
Dar S, Lazer T, Swanson S, Silverman J, Wasser C, Moskovtsev SI, Sojecki A, Librach CL.
Hum Reprod. 2015 Feb;30(2):345-52. doi: 10.1093/humrep/deu333. Epub 2014 Dec 17. PMID: 25518975

Impact of ventilatory modes on the breathing variability in mechanically ventilated infants.
Baudin F, Wu HT, Bordessoule A, Beck J, Jouvet P, Frasch MG, Emeriaud G.
Front Pediatr. 2014 Nov 25;2:132. doi: 10.3389/fped.2014.00132. eCollection 2014. PMID: 25505779