Xuesen Dong MD, PhD
Assistant Professor
X Dong
Vancouver General Hospital

Dr. Dong received medical school training from China before coming to Canada. He completed an MSc in Molecular and Cellular Biology at Laval University and a PhD in Physiology at the University of Toronto. He received post-doctoral training from the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto and the Vancouver Prostate Centre, University of British Columbia. He was a recipient of several scholarships for his doctoral and post-doctoral training. He was awarded as a Rising Star by Prostate Cancer Canada.


Research Synopsis

Dr. Dong’s laboratory investigates steroid receptors in collaborating with RNA splicing factors to control gene transcription and alternative RNA splicing in cells from human reproductive systems. We study how prostate cancer cells can switch off their dependency to androgens and progress into castration resistant cancers. We also study how myometrial cells can develop a functional withdrawal of progesterone at late pregnancy to change the myometrium from a dormant state to the contractile state for parturition.


Canadian Institute of Health Research, Prostate Cancer Canada

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Dong X, Shylnova O, Challis JR, Lye SJ. Identification and characterization of the PTB-associated splicing factor as a negative co-regulator of the progesterone receptor. J Biol Chem. 2005 Apr 8;280(14):13329-40.

Dong X, Sweet J, Challis JR, Brown T, Lye SJ. Transcriptional Activity of Androgen Receptor Is Modulated by Two RNA Splicing Factors, PSF and p54nrb. Mol Cell Biol. 2007 Jul;27(13): 4863-75.

Liu L, Li Y, Xie N, Shynlova O, Challis JR, Slater D, Lye S, Dong X. Proliferative action of the androgen receptor in human uterine myometrial cells--a key regulator for myometrium phenotype programming. J Clin Endocrinol Metab. 2013 Jan; 98 (1):218-27.

Yu Y, Liu L, Xie N, Xue H, Fazli L, Buttyan R, Wang Y, Gleave M, Dong X. Expression and function of the progesterone receptor in human prostate stroma provide novel insights to cell proliferation control. J Clin Endocrinol Metab. 2013 Jul; 98 (7):2887-96. 

Liu LL, Xie N, Sun S, Plymate S, Mostaghel E, Dong X. Mechanisms of the androgen receptor splicing in prostate cancer cells. Oncogene. 2014 Jun 12;33(24):3140-50.

Xie N, Cheng H, Lin D, Liu LL, Yang O, Jia L, Fazli L, Gleave ME, WangYZ, Rennie PS and Dong X. The Expression of Glucocorticoid Receptor is Negatively Regulated by Active Androgen Receptor Signaling in Prostate Tumors. Int J Cancer 2014 2014 Aug 20. doi: 10.1002/ijc.29147. 

Li H, Li Y, Morin D, Plymate S, Lye S, Dong X. The Androgen Receptor Mediates Anti-apoptotic Function in Myometrial Cells. Cell Death & Disease 2014 Jul 17;5:e1338. doi: 10.1038/cddis.2014.303.